KMID : 0882420130850010067
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Korean Journal of Medicine 2013 Volume.85 No. 1 p.67 ~ p.72
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A Case of Hemolytic Uremic Syndrome after Transarterial Chemoembolization with Cisplatin
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Yang Jee-Eun
Kim Kang-Mo Shim Ju-Hyun Lim Young-Suk Lee Han-Chu Chung Young-Hwa Lee Yung-Sang
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Abstract
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Hemolytic uremic syndrome (HUS) is a rare disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. These characteristics are related to the formation of platelet-rich microthrombi in the microvasculature. HUS is associated with a variety of etiologies, including cisplatin. Previously reported HUS cases after cisplatin administration were almost always related to systemic combination chemotherapy that included cisplatin. Transarterial chemoembolization (TACE) is commonly used in treatment of hepatocellular carcinoma, and most centers in Korea use cisplatin. A 70-year-old female with hepatocellular carcinoma was treated with TACE including cisplatin and subsequently developed clinical and laboratory findings compatible with HUS.
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KEYWORD
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Hemolytic uremic syndrome, Chemoembolization, Therapeutic, Cisplatin
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